Retrograde Amnesia from Electroconvulsive Shock

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BR-16A restricts development of electroconvulsive shock-induced retrograde amnesia.

Forty nine adult male Sprague Dawley rats were selected for rapid learning in a T-maze to study the effects of BR-16A, a herbal preparation on ECS-induced retrograde amnesia. Half the rats received 200 mg/kg BR-16A and the other half received vehicle alone. The rats were trained to run into the enclosed chamber of either the left or the right arm on a T-maze; a food pellet served as a reward in...

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Pre-electroconvulsive shock administration of calcium channel blockers reduces retrograde amnesia induced by ECS.

Effect of pre-electroconvulsive shock (ECS) administration of calcium channel blockers (CCBs) like verapamil, diltiazem, nifedipine, nimodipine, flunarizine and cinnarizine on retrograde amnesia induced by ECS was examined using passive avoidance paradigm in rats. The groups (Gr 1-7) of adult, male Wistar rats received true ECS with CCBs (5mg/kg; i.p) or vehicle (10 ml/kg; ip) and other groups ...

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Retrograde amnesia after electroconvulsive therapy: a temporary effect?

OBJECTIVE Although electroconvulsive therapy (ECT) is generally considered effective against depression, it remains controversial because of its association with retrograde memory loss. Here, we assessed memory after ECT in circumstances most likely to yield strong retrograde amnesia. METHOD A cohort of patients undergoing ECT for major depression was tested before and after ECT, and again at...

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Retrograde amnesia.

In humans, the phenomenon of temporally graded retrograde amnesia has been described in the clinic and the laboratory for more than 100 years. In the 1990s, retrograde amnesia began to be studied prospectively in experimental animals. We identified 13 published studies in which animals were given equivalent training at two or more separate times before damage to the fornix or hippocampal format...

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Retrograde amnesia in Parkinson's disease.

Retrograde amnesia was assessed in demented and non-demented Parkinson's patients using a test of remote memory spanning the years from 1920-1979. Results indicated that the demented patients 1) scored significantly below normal controls and 2) had equal impairment for all time periods. This pattern was like that seen in other dementing illnesses (i.e., Huntington's and Alzheimer's diseases), b...

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ژورنال

عنوان ژورنال: Science

سال: 1964

ISSN: 0036-8075,1095-9203

DOI: 10.1126/science.143.3609.973-a